The campus opened in January 1967 with a new 47,000 square foot administrative and classroom building. During the mid-1970s, the campus facilities were expanded to include a modern industrial training facility and 20,000 square feet of classroom, laboratory, and administrative space. Additional buildings of 26,000 square feet and 47,000 square feet were added in 1981 and 1996 respectively. In 2002 the 5,000 square foot Ammonia Refrigerant Building was added to the campus. In 2005 a 4,200 square foot Emergency Medical Services building was completed. In 2006 the state of the art Center of Innovation for Manufacturing Excellence was opened in the former Technology Center, building 500.

Located adjacent to Gainesville State College and the Lanier Career Center, the campus allows seamless learning opportunities from high school to technical college, to a four-year college, and beyond. Its location facilitates Oakwood Campus students taking advantage of dual enrollment at the high school and college level, thus fulfilling the college's mission of meeting the educational and technological needs of the community.

Forsyth Campus
The Forsyth Campus of Lanier Technical College, opened in 1998, is located at exit 13 off of GA 400. This location makes attending classes convenient for students coming from the North Fulton area as well as from Forsyth, Dawson, and Lumpkin counties. This lush, beautifully landscaped, 50+ acre campus includes pedestrian pathways and a memorial fountain - all of which enhance the natural beauty of the area. The campus's two modern buildings provide 57,000 square feet that integrate state-of-the-art technology with sleek design. The high-tech feel is complimented with a warm and welcoming quality to achieve and reflect the academic mission of the college.

Jackson County Campus
The Jackson County Campus is located in a shopping center in downtown Commerce. The expansion of the campus, completed in December 2004 has 20,000 square feet with 10 classrooms, auditorium, library, plus offices. Programs available in Commerce include Business Administrative Technology, Computer Information Systems, Industrial Systems Technology, and Practical Nursing.

Winder-Barrow Campus
Lanier Technical College expanded its service delivery area in July 2002 to include Barrow County. The Winder-Barrow Campus evolved through a partnership with the City of Winder, Barrow County government, Barrow County Board of Education, and the Barrow County Industrial Development Authority. The 25,000 square foot facility is located in the heart of downtown Winder. Programs available in Winder include Accounting, Business Administrative Technology, Computer Information Systems, Early Childhood Education, EMT, Fire Science, Medical Assisting, and Welding.

Dawson Campus
The Dawson Campus, opened in 2005, is located in downtown Dawsonville, in the newly renovated building of the former Dawson County High School. This 15,860 square foot building provides four general classroom/computer labs for Management, Accounting, Business Administrative Technology, CNA, and general core classes. In addition, there are spacious labs for the various Welding, Automotive, Plumbing, and Electrical Construction certificate and diploma programs. Students are also provided with an electronic media center and indoor and outdoor lounge areas.

Lanier Career Center
The Lanier Career Center is a joint partnership between the Hall County School System and Lanier Technical College. The campus opened in 2005 and is located adjacent to the Oakwood Campus at 2327 Tumbling Creek Road, Gainesville. The center provides traditional high school courses and technical college courses to high school students who want to pursue a technical college technical certificate of credit or diploma while enrolled in high school or who want technical electives offered in Lanier Technical College programs in lieu of other high school elective courses.

Northeast Georgia Health System Lanier Park Campus
The Radiologic Technology associate of applied science degree program is taught on the hospital campus which is located on White Sulfur Road in northern Gainesville. Suite 265 of the facility was renovated in 2005 to provide classroom and laboratory space as well as a student center and instructors' offices. The Radiologic Technology Center is a joint partnership between Northeast Georgia Health System and Lanier Technical College. Students participate in clinical rotations throughout Northeast Georgia Health System's radiology and imaging facilities.

Northeast Georgia Health System Main Campus
The part-time Licensed Practical Nursing diploma program is taught in the Pope Building on the main campus of the hospital in Gainesville. The Teaching Center is a joint partnership between Northeast Georgia Health System and Lanier Technical College. Students participate in clinical rotations throughout Northeast Georgia Health System's hospitals, clinics, nursing homes, and rehabilitative services facilities.